Although transfusion-transmitted infections are colmpicated by a variety of microorganisms, one of the most frequent posttransfusion infections may be hepatitis caused by either hepatitis B virus (HBV)or non-A, non-B hepatitis agent(hepatitis C
virus).
In this study, prevalence of HBsAg, anti-HCV, nontreponemal antibody to VDRl antigen and nonspecific antibody against HIV-1 in blood samples of 52.813 donors was investigated. In addition, significance of cut-off value(>65 units) of serum alanine
transaminase(ALT) in HBsAg and antiHCV, positive donors were evaluated, and the distribution of ABO groups and Rho(D) antigen wers investigated.
The prevalence of HBsAg, anti-HCV and HBsAg+anti-HCV positive donors were 5.9%, 0.6% and 0.6%, respectively. The incidence of antibody positivity to HIV-1 by ELISA test using AIDS virus antigen was 0.14%(73/52, 813), but all were negative by
confirmed
test by Western blots. The consistency of the increase of serum ALT level over cut-off value(>65 units) in HBsAg positive donors, anti-HCV positive donors and HBsAg+anti-HCV positive donors were 13.5%(421/3, 177), 18.1%(54/297) and 10.0%(34/388),
respectively. The incidence of nontreponemal antibody to VDRL antigen was 0.34%(175/52.813).
The highest frequency of ABO blood groups of donor's blood was A type(33.6%), followed by B(27.6%), 0(27.2%) and AB(11.3), and most donors(99.7%) were positive for Rho(D) antigen. These results indicate that to minimize the posttransfusion
infections
all samples of blood from donation should be tested for HBsAg and anti-HCV or other markers of HCV, anti-VDRL and anti-HIV-1 antibodies.
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